Scientist I, Process Development

AffyImmune Therapeutics (“Affy”), a clinical stage biotechnology company focused on developing technologies that expand the utility and improve the safety and efficacy of cell-based immunotherapy for cancer, is seeking a Process Development Scientist to help advance the use of CAR T therapy for solid tumors. As part of the CMC team, you will play a primary role in the crafting and operationalization of Affy’s strategy for enhancing and commercializing its cell therapy products. 

Reporting to Process Development Lead, you will join a small team at a dynamic startup. You will collaborate within and outside the company to develop and qualify assays, support technology transfer activities, and develop and execute a GMP compliant manufacturing process. With your process development expertise, organization, and enthusiasm, you will leave an indelible mark on Affy.

Location: Natick, Mass.



Process Development (90%)

  • Execute process development project plans and related characterization assays independently and in collaboration with CMC team members.
  • Characterize and optimize cell culture and expansion media formulations to ensure a robust T cell engineering process.
  • Plan and execute studies to determine the best path forward for current and future indications.
  • Develop robust manufacturing process to support later stage pipeline assets.
  • Independently author method documents, protocols, and reports.
  • Assist with data compilation and trending.
  • Present findings of studies to team and major stakeholders. 

Operational and Lab Support (10%)

  • Support maintenance of PD lab and inventory to ensure uninterrupted experiments and studies including but not limited to ordering and inventory, equipment maintenance, and waste management. 
  • Other duties as assigned.


  • B.S. Degree and 5-7 years of relevant experience, or M.S. Degree with 3-4 years of relevant experience required. Cell/gene therapy experience required. 
  • Experience with manufacturing scale processes using various gene and cell therapy equipment and technologies (e.g. for cell isolation, transduction, expansion, wash, harvest) preferred. 
  • Experience or familiarity with in-process/drug product characterization assays for cell and gene therapy (e.g. automated cell counting, flow cytometry).
  • Strong sense of urgency and excellence in prioritization, planning, and execution
  • Experience authoring and reviewing SOPs and batch records.
  • Flexibility to work on multiple projects as the portfolio evolves over time.
  • Meticulous attention to detail, including capacity to conduct thorough self-reviews.
  • Highly organized, collaborative, and motivated in a fast-paced startup environment.
  • Comfort with Microsoft Office (PowerPoint, Excel, Word), and GraphPad Prism (or other data analysis software).

This is a salaried, benefit-eligible position.

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