Real-Time CAR T Cell Monitoring
CAR T cell therapies can sometimes lead to severe toxicities, primarily due to a condition called cytokine release syndrome (CRS). CRS is caused by a large and rapid release of cytokines into the blood by the activated CAR T cells themselves, sometimes triggered by extensive killing of tumor cells. Although treatable, careful monitoring of the patient is required in order to detect CRS and other potentially severe toxicities at their earliest onset.
AffyImmune has developed a tracking system that is engineered into CAR T cells to monitor, in real-time, the distribution and activity of CAR T cells within the body after administration to the patient. This unique tracking system provides information on the functional status of the cells, showing whether cells are multiplying at the site of cancer or in normal tissues. This helps predict potential CRS or other severe toxicities and prepare for treatment.
AffyImmune’s proprietary CAR T Cell tracking technology is based on the expression of a marker, somatostatin receptor 2 (SSTR2), on our engineered CAR T cells, which can then be detected with the clinically approved PET/CT imaging probe 68Ga-DOTATATE. In the future, SSTR2 has the potential to be used as a safety switch and activity modulator to further increase safety and efficacy of our CAR T therapies.